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Engineering cellular symphonies out of transcriptional noise

Development unfolds through a series of orchestrated spatial and temporal gene-expression patterns. Despite relying on the noisy process of transcription, expression patterns remain robust to myriad disturbances. To achieve the goal of building complex tissues from the bottom up, synthetic biology must learn how to buffer and harness transcriptional noise.

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References

  1. 1.

    Rodriguez, J. et al. Intrinsic dynamics of a human gene reveal the basis of expression heterogeneity. Cell 176, 213–226 (2019).

    CAS  Article  Google Scholar 

  2. 2.

    Shrinivas, K. et al. Enhancer features that drive formation of transcriptional condensates. Mol. Cell 75, 549–561 (2019).

    CAS  Article  Google Scholar 

  3. 3.

    Henninger, J. E. et al. RNA-mediated feedback control of transcriptional condensates. Cell 184, 207–225 (2021).

    CAS  Article  Google Scholar 

  4. 4.

    Quarton, T. et al. Uncoupling gene expression noise along the central dogma using genome engineered human cell lines. Nucleic Acids Res. 48, 9406–9413 (2020).

    CAS  Article  Google Scholar 

  5. 5.

    Virk, R. K. A. et al. Disordered chromatin packing regulates phenotypic plasticity. Science Adv. 6, eaax6232 (2020).

    CAS  Article  Google Scholar 

  6. 6.

    Babos, K. N. et al. Mitigating antagonism between transcription and proliferation allows near-deterministic cellular reprogramming. Cell Stem Cell. 25, 486–500 (2019).

    CAS  Article  Google Scholar 

  7. 7.

    Desai, R. V. et al. Discovery of a cellular mechanism regulating transcriptional noise. Preprint at bioRxiv https://doi.org/10.1101/2020.06.29.128439 (2020).

  8. 8.

    Zinani, O. Q. H. et al. Pairing of segmentation clock genes drives robust pattern formation. Nature 589, 431–436 (2021).

    CAS  Article  Google Scholar 

  9. 9.

    De Simone, A. et al. Control of osteoblast regeneration by a train of Erk activity waves. Nature 590, 129–133 (2021).

    Article  Google Scholar 

  10. 10.

    Toda, S. et al. Programming self-organizing multicellular structures with synthetic cell–cell signaling. Science 361, 156–162 (2018).

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Correspondence to Kate E. Galloway.

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Johnstone, C.P., Galloway, K.E. Engineering cellular symphonies out of transcriptional noise. Nat Rev Mol Cell Biol 22, 369–370 (2021). https://doi.org/10.1038/s41580-021-00359-5

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