Mechano-genomic regulation of coronaviruses and its interplay with ageing

Coronaviruses employ various nuclear signalling mechanisms for their propagation. Here we link replication of coronaviruses, including SARS-CoV-2, the coronavirus disease 2019 (COVID-19)-causing virus, with cytoskeleton-dependent signalling and 3D genome organization. This link could provide novel insights into the high coronavirus pathogenicity in certain cellular states, particularly those associated with ageing.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    de Wit, E., van Doremalen, N., Falzarano, D. & Munster, V. J. SARS and MERS: recent insights into emerging coronaviruses. Nat. Rev. Micro. 14, 523 (2016).

  2. 2.

    Poppe, M. et al. The NF-κB-dependent and-independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells. PLoS Pathog. 13, e1006286 (2017).

  3. 3.

    Uhler, C. & Shivashankar, G. V. Regulation of genome organization and gene expression by nuclear mechanotransduction. Nat. Rev. Mol. Cell Biol. 18, 717–727 (2017).

  4. 4.

    Discher, D. E. et al. Matrix mechanosensing: from scaling concepts in’omics data to mechanisms in the nucleus, regeneration, and cancer. Ann. Rev. Biophys. 46, 295–315 (2017).

  5. 5.

    Jain, N., Iyer, K. V., Kumar, A. & Shivashankar, G. V. Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility. Proc. Natl Acad. Sci. USA 110, 11349–11354 (2013).

  6. 6.

    Wang, Y., Nagarajan, M., Uhler, C. & Shivashankar, G. V. Orientation and repositioning of chromosomes correlate with cell geometry–dependent gene expression. Mol. Biol. Cell 28, 1997–2009 (2017).

  7. 7.

    Damodaran, K. et al. Compressive force induces reversible chromatin condensation and cell geometry–dependent transcriptional response. Mol. Biol. Cell 29, 3039–3051 (2018).

  8. 8.

    Mitra, A. et al. Cell geometry dictates TNFα-induced genome response. Proc. Natl Acad. Sci. USA 114, E3882–E3891 (2017).

  9. 9.

    Uhler, C. & Shivashankar, G. V. Nuclear mechanopathology and cancer diagnosis. Trends Cancer 4, 320–331 (2018).

  10. 10.

    Wang, Y., Squires, C., Belyaeva, A. & Uhler, C. Direct estimation of differences in causal graphs. Adv. Neural Inf. Process. Syst. 31 (2018).

Download references

Acknowledgements

C.U. and G.V.S. acknowledge funding from ETH Zurich and the Paul Scherrer Institute, Switzerland, as well as helpful discussions with members of their respective laboratories.

Author information

Affiliations

Authors

Corresponding author

Correspondence to G. V. Shivashankar.

Ethics declarations

Competing interests

The authors declare no competing interests.

Supplementary Information

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Uhler, C., Shivashankar, G. Mechano-genomic regulation of coronaviruses and its interplay with ageing. Nat Rev Mol Cell Biol 21, 247–248 (2020). https://doi.org/10.1038/s41580-020-0242-z

Download citation