Coronaviruses employ various nuclear signalling mechanisms for their propagation. Here we link replication of coronaviruses, including SARS-CoV-2, the coronavirus disease 2019 (COVID-19)-causing virus, with cytoskeleton-dependent signalling and 3D genome organization. This link could provide novel insights into the high coronavirus pathogenicity in certain cellular states, particularly those associated with ageing.
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C.U. and G.V.S. acknowledge funding from ETH Zurich and the Paul Scherrer Institute, Switzerland, as well as helpful discussions with members of their respective laboratories.
The authors declare no competing interests.
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Uhler, C., Shivashankar, G. Mechano-genomic regulation of coronaviruses and its interplay with ageing. Nat Rev Mol Cell Biol 21, 247–248 (2020). https://doi.org/10.1038/s41580-020-0242-z