Locus-specific chromatin isolation

A Publisher Correction to this article was published on 03 February 2020

This article has been updated

Identifying factors bound to specific genomic loci in an unbiased manner is the holy grail of chromatin research, because it would provide an ultimate description of locus function. In this Comment, we explain why purifying a single locus represents a major technical challenge and provide recommendations for achieving this goal.

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  • 03 February 2020

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.


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Work in the laboratory of J. Dejardin is supported by grants from ARC Equipe Labélisée 2016, the ERC CoG METACHROM, from INCA, from the Fondation Schlumberger pour l’Education et la Recherche and from Merck (MSD). The laboratory of M. Vermeulen is part of the Oncode Institute, which is partly funded by the Dutch Cancer Society.

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Correspondence to Michiel Vermeulen or Jérôme Déjardin.

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The authors declare no competing interests.

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Vermeulen, M., Déjardin, J. Locus-specific chromatin isolation. Nat Rev Mol Cell Biol 21, 249–250 (2020).

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