Nature Reviews Molecular Cell Biology (2020) https://doi.org/10.1038/s41580-020-00288-9 Published online 24 September 2020

Reference 167 was added to the reference list, and the following statement was added to the last paragraph of the ‘Disease resistance’ subsection: “However, careful assessment of the CRISPR–Cas9 approach should still be considered, as the technology has been reported to generate plants with no or limited levels of virus resistance, thereby driving rapid generation of viral escapes167.” The changes have been made in the HTML and PDF versions of the article.