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Decelerating ageing and biological clocks by autophagy

Ageing is the most important risk factor for the majority of human pathologies. We propose the concept that the advancement of the hallmarks of ageing is dictated by several distinct biological clocks that can be decelerated by the induction of autophagy. This ‘time dilation’ delays the time-dependent manifestation of multiple diseases.

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Correspondence to Guido Kroemer.

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G.K. is a scientific cofounder for Samsara Therapeutics. The other author declares no conflict of interest.

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Lopez-Otín, C., Kroemer, G. Decelerating ageing and biological clocks by autophagy. Nat Rev Mol Cell Biol 20, 385–386 (2019).

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