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The importance of non-histone protein methylation in cancer therapy

Epigenetic regulatory enzymes are generally considered innovative targets for cancer therapy and several histone methyltransferase inhibitors are currently being evaluated in phase I and phase II clinical trials. In this commentary, we discuss the need for better functional understanding of histone methyltransferases and especially of their potential non-histone substrates.

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Correspondence to Frank Lyko.

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Rodríguez-Paredes, M., Lyko, F. The importance of non-histone protein methylation in cancer therapy. Nat Rev Mol Cell Biol 20, 569–570 (2019).

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