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Blocking autophagy to starve pancreatic cancer

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References

    Original articles

    1. Bryant, K. L. et al. Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer. Nat. Med. https://doi.org/10.1038/s41591-019-0368-8 (2019)

    2. Kinsey, C. G. et al. Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers. Nat. Med. https://doi.org/10.1038/s41591-019-0367-9 (2019)

    3. Yang, S. et al. Pancreatic cancers require autophagy for tumor growth. Genes Dev. 25, 717–729 (2011)

    4. Yang, A. et al. Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations. Cancer Discov. 4, 905–913 (2014)

    Further reading

    1. Dikic, I. & Elazar, Z. Mechanism and medical implications of mammalian autophagy. Nat. Rev. Mol. Cell Biol. 19, 349–364 (2018)

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    Competing interests

    The authors declare no competing interests.

    Correspondence to Channing J. Der.

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