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150 years of Darwin’s theory of intercellular flow of hereditary information


In 1868, Charles Darwin published his Pangenesis theory, which proposed a mechanism for the flow of hereditary information between cells and generations. Pangenesis has since been disputed, but emerging evidence of cell-to-cell communication urges the reconsideration of this 150-year-old theory.

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The authors thank R. M. Roberts for constructive comments and members of the Chen laboratory for discussions. Research in the Chen laboratory is supported by the NIH (R01HD092431).

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Correspondence to Qi Chen.

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Liu, Y., Chen, Q. 150 years of Darwin’s theory of intercellular flow of hereditary information. Nat Rev Mol Cell Biol 19, 749–750 (2018).

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