Nature Reviews Molecular Cell Biology (2018) https://doi.org/10.1038/s41580-018-0033-y Published online 13 July 2018

In the original article a Note added in proof was not included. This has now been amended. In addition, the sentence highlighting ref. 162 referred to Bcl-1 as a negative regulator of beclin 1. This was corrected to BCL-2.