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The challenges facing synthetic biology in eukaryotes

Nature Reviews Molecular Cell Biologyvolume 19pages481482 (2018) | Download Citation

Synthetic biology is maturing into a true engineering discipline for model microorganisms, but remains far from straightforward for most eukaryotes. Here, we outline the key challenges facing those trying to engineer biology across eukaryota and suggest areas of focus that will aid future progress.

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For valuable input, we thank K. Polizzi, K. Haynes, D. Mehta, M. Elowitz and all those who voiced opinions on this subject on Twitter. F.C. is supported by the Imperial College London Junior Research Fellowship Scheme.

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  1. Department of Chemical Engineering, Imperial College London, London, UK

    • Francesca Ceroni
  2. Imperial College Centre for Synthetic Biology, Imperial College London, London, UK

    • Francesca Ceroni
    •  & Tom Ellis
  3. Department of Bioengineering, Imperial College London, London, UK

    • Tom Ellis
  4. Visiting Associate, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA

    • Tom Ellis


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Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Tom Ellis.

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