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Small cells with big secrets

This Genome Watch highlights how combining next-generation sequencing and imaging technologies sheds light on the diverse and intricate symbiotic relationships of uncultivated archaea and bacteria.

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  1. Castelle, C. J. & Banfield, J. F. Major new microbial groups expand diversity and alter our understanding of the tree of life. Cell 172, 1181–1197 (2018).

    Article  CAS  PubMed  Google Scholar 

  2. He, C. et al. Genome-resolved metagenomics reveals site-specific diversity of episymbiotic CPR bacteria and DPANN archaea in groundwater ecosystems. Nat. Microbiol. 6, 354–365 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Xie, B. et al. Type IV pili trigger episymbiotic association of Saccharibacteria with its bacterial host. Proc. Natl Acad. Sci. USA 119, e2215990119 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Kuroda, K. et al. Symbiosis between Candidatus Patescibacteria and Archaea discovered in wastewater-treating bioreactors. mBio 13, e0171122 (2022).

    Article  PubMed  Google Scholar 

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Correspondence to Jean-Marie Volland.

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Volland, JM. Small cells with big secrets. Nat Rev Microbiol 21, 414 (2023).

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