Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Putting a twist in syphilis vaccine development

This Genome Watch highlights how population genomic strategies can aid in the development of an effective syphilis vaccine.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. Beale, M. A. et al. Global phylogeny of Treponema pallidum lineages reveals recent expansion and spread of contemporary syphilis. Nat. Microbiol. 6, 1549–1560 (2021).

    Article  CAS  Google Scholar 

  2. Lieberman, N. A. P. et al. Treponema pallidum genome sequencing from six continents reveals variability in vaccine candidate genes and dominance of Nichols clade strains in Madagascar. PLoS Negl. Trop. Dis. 15, e0010063 (2021).

    Article  CAS  Google Scholar 

  3. Taouk, M. L. et al. Characterisation of Treponema pallidum lineages within the contemporary syphilis outbreak in Australia: a genomic epidemiological analysis. Lancet Microbe 3, e417–e426 (2022).

    Article  CAS  Google Scholar 

  4. Romeis, E. et al. Genetic engineering of Treponema pallidum subsp. pallidum, the syphilis spirochete. PLoS Pathog. 17, e1009612 (2021).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Linda Grillová.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Grillová, L. Putting a twist in syphilis vaccine development. Nat Rev Microbiol 20, 577 (2022).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing