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  • Genome Watch
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Putting a twist in syphilis vaccine development

This Genome Watch highlights how population genomic strategies can aid in the development of an effective syphilis vaccine.

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References

  1. Beale, M. A. et al. Global phylogeny of Treponema pallidum lineages reveals recent expansion and spread of contemporary syphilis. Nat. Microbiol. 6, 1549–1560 (2021).

    Article  CAS  Google Scholar 

  2. Lieberman, N. A. P. et al. Treponema pallidum genome sequencing from six continents reveals variability in vaccine candidate genes and dominance of Nichols clade strains in Madagascar. PLoS Negl. Trop. Dis. 15, e0010063 (2021).

    Article  CAS  Google Scholar 

  3. Taouk, M. L. et al. Characterisation of Treponema pallidum lineages within the contemporary syphilis outbreak in Australia: a genomic epidemiological analysis. Lancet Microbe 3, e417–e426 (2022).

    Article  CAS  Google Scholar 

  4. Romeis, E. et al. Genetic engineering of Treponema pallidum subsp. pallidum, the syphilis spirochete. PLoS Pathog. 17, e1009612 (2021).

    Article  CAS  Google Scholar 

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Correspondence to Linda Grillová.

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Grillová, L. Putting a twist in syphilis vaccine development. Nat Rev Microbiol 20, 577 (2022). https://doi.org/10.1038/s41579-022-00784-z

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