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Diversity of microbial defence systems

This month’s Genome Watch highlights the systematic discovery of defence systems, paving the way to decode novel genetic functions and further our understanding of microbial warfare.

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  1. Doron, S. et al. Systematic discovery of antiphage defense systems in the microbial pangenome. Science 359, eaar4120 (2018).

    Article  Google Scholar 

  2. Payne, L. J. et al. Identification and classification of antiviral defence systems in bacteria and archaea with PADLOC reveals new system types. Nucleic Acids Res. 49, 10868–10878 (2021).

    Article  CAS  Google Scholar 

  3. Tesson, F. et al. Systematic and quantitative view of the antiviral arsenal of prokaryotes. Preprint at bioRxiv (2021).

    Article  Google Scholar 

  4. Abby, S. S. et al. MacSyFinder: a program to mine genomes for molecular systems with an application to CRISPR-Cas systems. PLoS ONE 9, e110726 (2014).

    Article  Google Scholar 

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Correspondence to Adrian Cazares.

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Cazares, A., Figueroa, W. & Cazares, D. Diversity of microbial defence systems. Nat Rev Microbiol 20, 191 (2022).

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