Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Genome Watch
  • Published:

New keys to unlock the treasure trove of microbial natural products

Nature Reviews Microbiology volume 19, page 683 (2021)Cite this article

Subjects

This month’s Genome Watch highlights how recent advances in computational identification of biosynthetic gene clusters (BGCs), and in their experimental manipulation, are opening new avenues to access novel secondary metabolites.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Kautsar, S. A. et al. BiG-FAM: the biosynthetic gene cluster families database. Nucleic Acids Res. 49, D490–D497 (2021).

    Article  CAS  Google Scholar 

  2. Qi, Y., Nepal, K. K. & Blodgett, J. A. V. A comparative metabologenomic approach reveals mechanistic insights into Streptomyces antibiotic crypticity. Proc. Natl Acad. Sci. USA 118, e2103515118 (2021).

    Article  CAS  Google Scholar 

  3. Park, J., Yim, S. S. & Wang, H. H. High-throughput transcriptional characterization of regulatory sequences from bacterial biosynthetic gene clusters. ACS Synth. Biol. 10, 1859–1873 (2021).

    Article  CAS  Google Scholar 

  4. Enghiad, B. et al. Cas12a-assisted precise targeted cloning using in vivo Cre-lox recombination. Nat. Commun. 12, 1171 (2021).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. DOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA

    Daniel W. Udwary, Hiroshi Otani & Nigel J. Mouncey

Authors
  1. Daniel W. Udwary
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hiroshi Otani
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nigel J. Mouncey
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nigel J. Mouncey.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Udwary, D.W., Otani, H. & Mouncey, N.J. New keys to unlock the treasure trove of microbial natural products. Nat Rev Microbiol 19, 683 (2021). https://doi.org/10.1038/s41579-021-00631-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41579-021-00631-7

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing