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SYMBIOSIS

Beating in on a stable partnership

Although our understanding of the importance of the partnership of humans and their microbiome in health and disease is rapidly developing, its complexity is high and support for causality is scarce. Model organisms serve to tackle these limitations. Recent updates on the squid–vibrio symbiosis show mechanistic details that underlie the establishment and maintenance of a symbiotic association along the apical surfaces of an animal epithelium.

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Fig. 1: Mechanisms involved in establishing and maintaining the squid–vibrio symbiosis.

References

  1. Visick, K. L., Stabb, E. V. & Ruby, E. G. A lasting symbiosis: how Vibrio fischeri finds a squid partner and persists within its natural host. Nat. Rev. Microbiol. https://doi.org/10.1038/s41579-021-00557-0 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Nyholm, S. V. & McFall-Ngai, M. J. A lasting symbiosis: how the Hawaiian bobtail squid finds and keeps its bioluminescent bacterial partner. Nat. Rev. Microbiol. https://doi.org/10.1038/s41579-021-00567-y (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Koch, E. J., Moriano-Gutierrez, S., Ruby, E. G., McFall-Ngai, M. & Liebeke, M. The impact of persistent colonization by Vibrio fischeri on the metabolome of the host squid Euprymna scolopes. J. Exp. Biol. 223, (2020).

  4. Schwartzman, J. A. et al. The chemistry of negotiation: rhythmic, glycan-driven acidification in a symbiotic conversation. Proc. Natl Acad. Sci. 112, 566–571 (2015).

    Article  CAS  Google Scholar 

  5. Brooks, J. F. & Mandel, M. J. The histidine kinase BinK is a negative regulator of biofilm formation and squid colonization. J. Bacteriol. 198, 2596–2607 (2016).

    Article  Google Scholar 

  6. Bultman, K. M., Cecere, A. G., Miyashiro, T., Septer, A. N. & Mandel, M. J. Draft genome sequences of type VI secretion system-encoding Vibrio fischeri strains FQ-A001 and ES401. Microbiol. Resour. Announc. 8, e00385-19 (2019).

    Article  Google Scholar 

  7. Guckes, K. R. et al. Incompatibility of Vibrio fischeri strains during symbiosis establishment depends on two functionally redundant hcp genes. J. Bacteriol. 201, e00221-19 (2019).

    Article  Google Scholar 

  8. Moriano-Gutierrez, S. et al. The noncoding small RNA SsrA is released by Vibrio fischeri and modulates critical host responses. PLoS Biol. 18, e3000934 (2020).

    Article  CAS  Google Scholar 

  9. Koehler, S. et al. The model squid–vibrio symbiosis provides a window into the impact of strain-and species-level differences during the initial stages of symbiont engagement. Environ. Microbiol. 21, 3269–3283 (2019).

    Article  CAS  Google Scholar 

  10. Bosch, T. C. G. & Hadfield, M. G. Cellular Dialogues in the Holobiont (CRC Press, 2020).

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Correspondence to Thomas C. G. Bosch.

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Giez, C., Bosch, T.C.G. Beating in on a stable partnership. Nat Rev Microbiol 19, 619–620 (2021). https://doi.org/10.1038/s41579-021-00575-y

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