Although our understanding of the importance of the partnership of humans and their microbiome in health and disease is rapidly developing, its complexity is high and support for causality is scarce. Model organisms serve to tackle these limitations. Recent updates on the squid–vibrio symbiosis show mechanistic details that underlie the establishment and maintenance of a symbiotic association along the apical surfaces of an animal epithelium.
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References
Visick, K. L., Stabb, E. V. & Ruby, E. G. A lasting symbiosis: how Vibrio fischeri finds a squid partner and persists within its natural host. Nat. Rev. Microbiol. https://doi.org/10.1038/s41579-021-00557-0 (2021).
Nyholm, S. V. & McFall-Ngai, M. J. A lasting symbiosis: how the Hawaiian bobtail squid finds and keeps its bioluminescent bacterial partner. Nat. Rev. Microbiol. https://doi.org/10.1038/s41579-021-00567-y (2021).
Koch, E. J., Moriano-Gutierrez, S., Ruby, E. G., McFall-Ngai, M. & Liebeke, M. The impact of persistent colonization by Vibrio fischeri on the metabolome of the host squid Euprymna scolopes. J. Exp. Biol. 223, (2020).
Schwartzman, J. A. et al. The chemistry of negotiation: rhythmic, glycan-driven acidification in a symbiotic conversation. Proc. Natl Acad. Sci. 112, 566–571 (2015).
Brooks, J. F. & Mandel, M. J. The histidine kinase BinK is a negative regulator of biofilm formation and squid colonization. J. Bacteriol. 198, 2596–2607 (2016).
Bultman, K. M., Cecere, A. G., Miyashiro, T., Septer, A. N. & Mandel, M. J. Draft genome sequences of type VI secretion system-encoding Vibrio fischeri strains FQ-A001 and ES401. Microbiol. Resour. Announc. 8, e00385-19 (2019).
Guckes, K. R. et al. Incompatibility of Vibrio fischeri strains during symbiosis establishment depends on two functionally redundant hcp genes. J. Bacteriol. 201, e00221-19 (2019).
Moriano-Gutierrez, S. et al. The noncoding small RNA SsrA is released by Vibrio fischeri and modulates critical host responses. PLoS Biol. 18, e3000934 (2020).
Koehler, S. et al. The model squid–vibrio symbiosis provides a window into the impact of strain-and species-level differences during the initial stages of symbiont engagement. Environ. Microbiol. 21, 3269–3283 (2019).
Bosch, T. C. G. & Hadfield, M. G. Cellular Dialogues in the Holobiont (CRC Press, 2020).
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Giez, C., Bosch, T.C.G. Beating in on a stable partnership. Nat Rev Microbiol 19, 619–620 (2021). https://doi.org/10.1038/s41579-021-00575-y
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DOI: https://doi.org/10.1038/s41579-021-00575-y