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Resisting antimicrobial resistance

To control antimicrobial resistance (AMR) will require approaches to develop, share and preserve antibiotics that are scaled to the scientific, economic and ethical dimensions of the crisis. The three cooperative, interdisciplinary, international councils proposed here exemplify what this will require.

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  1. Roope, L. S. J. et al. The challenge of antimicrobial resistance: what economics can contribute. Science 364, eaau4679 (2019).

    Article  CAS  Google Scholar 

  2. The Review on Antimicrobial Resistance. Tackling drug-resistant infections globally: final report and recommendations. (2016).

  3. Nathan, C. & Cars, O. Antibiotic resistance — problems, progress, and prospects. N. Engl. J. Med. 371, 1761–1763 (2014).

    Article  Google Scholar 

  4. Laxminarayan, R., Sridhar, D., Blaser, M., Wang, M. & Woolhouse, M. Achieving global targets for antimicrobial resistance. Science 353, 874–875 (2016).

    Article  CAS  Google Scholar 

  5. Nathan, C. Aligning pharmaceutical innovation with medical need. Nat. Med. 13, 304–308 (2007).

    Article  CAS  Google Scholar 

  6. Nielsen, T. B., Brass, E. P., Gilbert, D. N., Bartlett, J. G. & Spellberg, B. Sustainable discovery and development of antibiotics - is a nonprofit approach the future? N. Engl. J. Med. 381, 503–505 (2019).

    Article  Google Scholar 

  7. Outterson, K. et al. Delinking investment in antibiotic research and development from sales revenues: the challenges of transforming a promising idea into reality. PLoS Med. 13, e1002043 (2016).

    Article  Google Scholar 

  8. Årdal, C. et al. Drive-AB Report. Revitalizing the antibiotic pipeline. (2018).

  9. Barbier, E. Sustainability: tax ‘societal ills’ to save the planet. Nature 483, 30 (2012).

    Article  CAS  Google Scholar 

  10. Nathan, C. F. Cooperative development of antimicrobials: looking back to look ahead. Nat. Rev. Microbiol. 13, 651–657 (2015).

    Article  CAS  Google Scholar 

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Correspondence to Carl Nathan.

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Combating Antibiotic Resistant Bacteria Biopharmaceutical Accelerator (CARB-X):

Global Antibiotic Research and Development Partnership (GARDP):

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Nathan, C. Resisting antimicrobial resistance. Nat Rev Microbiol 18, 259–260 (2020).

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