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This month’s Under the Lens discusses the use of a novel label-free imaging method to study pilus dynamics at high spatial and temporal resolution.

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  1. 1.

    Craig, L., Forest, K. T. & Maier, B. Type IV pili: dynamics, biophysics and functional consequences. Nat. Rev. Microbiol. https://doi.org/10.1038/s41579-019-0195-4 (2019).

  2. 2.

    Talà, L. et al. Pseudomonas aeruginosa orchestrates twitching motility by sequential control of type IV pili movements. Nat. Microbiol. 4, 774–780 (2019).

  3. 3.

    Lindfors, K. et al. Detection and spectroscopy of gold nanoparticles using supercontinuum white light confocal microscopy. Phys. Rev. Lett. 93, 037401 (2004).

  4. 4.

    Young, G. et al. Quantitative mass imaging of single biological macromolecules. Science 360, 423–427 (2018).

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Correspondence to Samuel J. Hickman.

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