MICROBIOME

Diet and the mammary gland microbiome

Diet is one of the factors that shape the gut microbiome; however, little is known about the influence of diet on the microbiome in other tissues or organs. Shively et al. used a non-human primate model to investigate whether diet can modify the breast tissue-specific microbiota. Animals fed a Mediterranean diet had higher levels of Lactobacillus populations in their mammary gland tissues, whereas consumption of a Western diet led to increased levels of bacteria in the Ruminococcus, Lachnospiraceae, Oscillospira and Coprococcus genera. These results highlight both differences and similarities of the diet-mediated modulation of the microbiota in the gut and mammary gland tissues. A Mediterranean diet also led to increased levels of bile acid metabolites and bacterial-modified bioactive compounds, which may affect inflammation in the breast and modulate breast cancer risk. Thus, diet influences microbiome populations not only in the intestinal tract but also at distal sites.

References

Original article

  1. Shively, C. A. et al. Consumption of Mediterranean versus Western diet leads to distinct mammary gland microbiome populations. Cell Rep. 25, 47–56 (2018)

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Andrea Du Toit.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Du Toit, A. Diet and the mammary gland microbiome. Nat Rev Microbiol 16, 717 (2018). https://doi.org/10.1038/s41579-018-0101-5

Download citation

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing