Chirality has a key role in the synthesis of biomolecules and the development of life. Although the effects of many chiral molecules or materials on biological processes have been studied for over 150 years, research aimed at understanding the relationship between the intrinsic chirality of engineered materials and bioresponses is still at the beginning. In this Perspective article, we present three classes of intrinsically chiral engineered materials: carbon dots, metal-based materials and patterned geometries. We elaborate on these chiral materials in terms of design, structural and functional differences between the enantiomers and effects of intrinsic chirality on biological processes. Finally, we address the safety concerns, challenges, opportunities and directions for future development of intrinsically chiral materials.
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Dedicated to the 70th birthday of M. Prato. The authors greatly acknowledge the financial support from the National Natural Science Foundation of China (No. 82100974), Shandong Province Key Research and Development Program (No. 2021ZDSYS18), Shandong Province Natural Science Foundation (No. ZR2021QH241), Young Elite Scientist Support Program by CSA (No. 2021PYRC001) and Qilu Young Scholars Program of Shandong University. This work was partly supported by the Interdisciplinary Thematic Institute SysChem via the IdEx Unistra (ANR-10-IDEX-0002) within the programme ‘Investissement d’Avenir’. A.B. acknowledges the Centre National de la Recherche Scientifique and the International Center for Frontier Research in Chemistry.
The authors declare no competing interests.
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Ma, B., Bianco, A. Regulation of biological processes by intrinsically chiral engineered materials. Nat Rev Mater 8, 403–413 (2023). https://doi.org/10.1038/s41578-023-00561-1