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Peptide-based liquid droplets as emerging delivery vehicles

Peptides are small yet versatile building blocks of biomaterials. This Comment highlights recent progress in the design of liquid-like microdroplets, or coacervates, based on peptides and produced through liquid–liquid phase separation. This emerging platform holds promise as efficacious delivery vehicles for multi-purpose biomedical applications.

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Fig. 1: Peptide-based microdroplets.


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E.S. acknowledges financial support from the European Research Council (ERC) through the European Union’s Horizon 2020 research and innovation programme (grant no. 851963). A.M. gratefully acknowledges financial support from the Singapore Ministry of Education (MOE) through an Academic Research (AcRF) Tier 3 grant (grant no. MOE 2019-T3-1-012).

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Correspondence to Jianhui Liu, Evan Spruijt, Ali Miserez or Robert Langer.

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Liu, J., Spruijt, E., Miserez, A. et al. Peptide-based liquid droplets as emerging delivery vehicles. Nat Rev Mater 8, 139–141 (2023).

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