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Design and applications of man-made biomimetic fibrillar hydrogels

Nature Reviews Materials volume 4, pages 99–115 (2019)Cite this article

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Abstract

Many extracellular matrices (ECMs) have a filamentous architecture, which influences cell growth and phenotype and imparts tissues with specific properties. Man-made fibrillar hydrogels can function as biomimetic materials to reproduce the filamentous nature and properties of ECMs and to serve as scaffolds for 3D cell culture and tissue engineering. Different types of synthetic nanofibrillar hydrogels have been developed, with diverse mechanisms of assembly and a variety of physical properties and applications. In this Review, we explore the design and properties of biomimetic man-made nanofibrillar hydrogels. We discuss the assembly of peptides, block copolymer worm-like micelles and filamentous nanoparticles into fibrillar hydrogels and investigate the relationship between structure and physical as well as biochemical properties. Potential applications for 3D cell culture and tissue engineering are examined, and the properties and structure of natural and man-made fibrillar hydrogels are compared. Finally, we critically assess current challenges and future directions of the field.

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Fig. 1: Nanofibrillar extracellular matrices.
Fig. 2: Assembly of man-made nanofibrillar hydrogels.
Fig. 3: Assembly of fibrillar hydrogels from molecular building blocks.
Fig. 4: Assembly of fibrillar hydrogels from colloidal particles.
Fig. 5: Anisotropy of fibrillar hydrogels.
Fig. 6: Structure and properties of fibrillar hydrogels.

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Acknowledgements

The authors are grateful to the Natural Sciences and Engineering Research Council (NSERC) of Canada (Discovery Grant) for their financial support. E.K. thanks the Canada Research Chairs Program. E.P. is grateful to the NSERC of Canada Graduate Scholarship-Doctoral Program.

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  1. Department of Chemistry, University of Toronto, Toronto, ON, Canada

    Elisabeth Prince & Eugenia Kumacheva

  2. Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada

    Eugenia Kumacheva

  3. Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, Canada

    Eugenia Kumacheva

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E.P. and E.K. wrote and edited the manuscript. E.P. researched data for the article.

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Prince, E., Kumacheva, E. Design and applications of man-made biomimetic fibrillar hydrogels. Nat Rev Mater 4, 99–115 (2019). https://doi.org/10.1038/s41578-018-0077-9

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