Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Immunotherapy

Organoids identify a role for IL-7 in coeliac disease

Nature Reviews Immunology volume 24, page 699 (2024)Cite this article

Subjects

Reporting in Nature, Santos et al. have used human organoids generated from individuals with coeliac disease to identify an unexpected role for IL-7 in the pathogenesis of this disease.

The authors used an air–liquid interface (ALI) system to generate organoids from human small intestinal biopsies. These organoids were embedded within a collagen matrix in an air-exposed transwell with access to medium with growth factors from an outer well via a permeable membrane. Organoids formed after three days of culture and could be expanded with epithelial proliferation for more than a year. Importantly, the organoids retained their diverse epithelial, mesenchymal and immune cell populations. Although the numbers of haematopoietic cells progressively declined during culture, these cells could be maintained for longer by supplementing the medium with cytokines.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

Original article

  • Santos, J. M. et al. A human autoimmune organoid model reveals IL-7 function in coeliac disease. Nature 632, 401–410 (2024)

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nature Reviews Immunology http://www.nature.com/nri/

    Yvonne Bordon

Authors
  1. Yvonne Bordon
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yvonne Bordon.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bordon, Y. Organoids identify a role for IL-7 in coeliac disease. Nat Rev Immunol 24, 699 (2024). https://doi.org/10.1038/s41577-024-01082-w

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41577-024-01082-w

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing