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Immunological studies in trans-individuals undergoing gender affirming hormone therapy

Nature Reviews Immunology volume 24, pages 697–698 (2024)Cite this article

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A Publisher Correction to this article was published on 10 September 2024

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Personalized medicine for all requires a shift in science and clinical culture that puts more emphasis on the sources of inter-individual variation. Important examples are sex differences in the presentation and severity of diseases, as well as in responses to therapy. Understanding the mechanisms that drive these differences is important in the context of individualized healthcare, and also to better understand the immune sequelae of long-term sex hormone supplementation or inhibition in transgender individuals.

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Fig. 1: Sex hormones in XX and XY individuals and effects of hormone modifying therapies.

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References

  1. Forsyth, K. S., Jiwrajka, N., Lovell, C. D., Toothacre, N. E. & Anguera, M. C. The conneXion between sex and immune responses. Nat. Rev. Immunol. 24, 487–502 (2024).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  2. Webb, K. et al. Sex and pubertal differences in the type 1 interferon pathway associate with both X chromosome number and serum sex hormone concentration. Front. Immunol. 9, 3167 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Grünhagel, B. et al. Reduction of IFN-I responses by plasmacytoid dendritic cells in a longitudinal trans men cohort. iScience 26, 108209 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Hill, B. G., Hodge, B. & Misischia, R. Lupus nephritis in a transgender woman on cross-sex hormone therapy: a case for the role of oestrogen in systemic lupus erythematosus. Lupus 29, 1807–1810 (2020).

    Article  PubMed  Google Scholar 

  5. Brodin, P. Immune determinants of COVID-19 disease presentation and severity. Nat. Med. 27, 28–33 (2021).

    Article  PubMed  CAS  Google Scholar 

  6. Youness, A., Miquel, C.-H. & Guéry, J.-C. Escape from X chromosome inactivation and the female predominance in autoimmune diseases. Int. J. Mol. Sci. 22, 1114 (2021).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Forsberg, L. A. et al. Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer. Nat. Genet. 46, 624–628 (2014).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. Sano, S. et al. Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality. Science 377, 292–297 (2022).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  9. Roman, A. K. S. et al. The human inactive X chromosome modulates expression of the active X chromosome. Cell Genom. 3, 100259 (2023).

    Article  Google Scholar 

  10. de Medeiros, S. F., Yamamoto, M. M. W., de Medeiros, M. A. S., Yamamoto, A. K. L. W. & Barbosa, B. B. Polycystic ovary syndrome and risks for COVID-19 infection: A comprehensive review. Rev. Endocr. Metabolic. Disord. 23, 251–264 (2022).

    Article  Google Scholar 

  11. Resztak, J. A. Analysis of transcriptional changes in the immune system associated with pubertal development in a longitudinal cohort of children with asthma. Nat. Commun. 14, 230 (2023).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  12. Robinson, G. A. et al. Investigating sex differences in T regulatory cells from cisgender and transgender healthy individuals and patients with autoimmune inflammatory disease: a cross-sectional study. Lancet Rheumatol. 4, e710–e724 (2022).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  13. Lakshmikanth, T. et al. Immune system adaptation during gender-affirming testosterone treatment. Nature https://doi.org/10.1038/s41586-024-07789-z (in the press).

  14. Ober, C., Loisel, D. & Gilad, Y. Sex-specific genetic architecture of human disease. Nat. Rev. Genet. 9, 911–922 (2008).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Authors and Affiliations

  1. Unit for Clinical Pediatrics, Dept. of Women’s and Children’s Health, Karolinska Institutet, Solna, Sweden

    Anna James & Petter Brodin

  2. Medical Research Council Laboratory of Medical Sciences (MRC LMS), Imperial College Hammersmith Campus, London, UK

    Petter Brodin

  3. Department of Immunology and Inflammation, Imperial College London, London, UK

    Petter Brodin

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  1. Anna James
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  2. Petter Brodin
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Correspondence to Petter Brodin.

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James, A., Brodin, P. Immunological studies in trans-individuals undergoing gender affirming hormone therapy. Nat Rev Immunol 24, 697–698 (2024). https://doi.org/10.1038/s41577-024-01070-0

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