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Neuroimmunology

A platelet-derived factor protects the ageing brain

Nature Reviews Immunology volume 23, page 614 (2023)Cite this article

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Systemic rejuvenating interventions — such as the transfer of blood plasma from young mice into older animals — can reverse age-related cognitive impairments, but the mechanisms involved are unclear. Now, the Villeda laboratory reports that platelet factor 4 (PF4; also known as CXCL4) is a blood-associated factor that reduces inflammation and cognitive decline in an age-dependent manner.

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  1. Nature Reviews Immunology http://www.nature.com/nri/

    Yvonne Bordon

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  1. Yvonne Bordon
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Correspondence to Yvonne Bordon.

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Bordon, Y. A platelet-derived factor protects the ageing brain. Nat Rev Immunol 23, 614 (2023). https://doi.org/10.1038/s41577-023-00939-w

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  • DOI: https://doi.org/10.1038/s41577-023-00939-w

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