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Expanding dendritic cell nomenclature in the single-cell era

Nature Reviews Immunology volume 22, pages 67–68 (2022)Cite this article

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Single-cell technologies have enabled extensive profiling studies of human and mouse tissues and the identification of an ever-growing number of transcriptional clusters within the dendritic cell (DC) lineage. Here, we discuss the importance of differentiating cell subsets from cell states when annotating DC clusters and propose a revised nomenclature of the DC lineage that integrates experimentally validated knowledge and unbiased transcriptomic profiling results.

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Authors and Affiliations

  1. Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore

    Florent Ginhoux

  2. Gustave Roussy Cancer Campus, Villejuif, France

    Florent Ginhoux

  3. Inserm U1015, Gustave Roussy, Villejuif, France

    Florent Ginhoux

  4. Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, Shanghai, China

    Florent Ginhoux

  5. Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore

    Florent Ginhoux

  6. Laboratory of Myeloid Cell Biology in Tissue Homeostasis and Regeneration, VIB-UGent Center for Inflammation Research, Ghent, Belgium

    Martin Guilliams

  7. Department of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium

    Martin Guilliams

  8. Precision Immunology Institute, Human Immune Monitoring Center, Department of Oncological Sciences Tisch Cancer Institute, New York, NY, USA

    Miriam Merad

Authors
  1. Florent Ginhoux
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  2. Martin Guilliams
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  3. Miriam Merad
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Corresponding authors

Correspondence to Florent Ginhoux, Martin Guilliams or Miriam Merad.

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The authors declare no competing interests.

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Peer review information

Nature Reviews Immunology thanks S. Nutt, who co-reviewed with M. Chopin, and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

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Ginhoux, F., Guilliams, M. & Merad, M. Expanding dendritic cell nomenclature in the single-cell era. Nat Rev Immunol 22, 67–68 (2022). https://doi.org/10.1038/s41577-022-00675-7

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