Single-cell technologies have enabled extensive profiling studies of human and mouse tissues and the identification of an ever-growing number of transcriptional clusters within the dendritic cell (DC) lineage. Here, we discuss the importance of differentiating cell subsets from cell states when annotating DC clusters and propose a revised nomenclature of the DC lineage that integrates experimentally validated knowledge and unbiased transcriptomic profiling results.
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The authors declare no competing interests.
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Nature Reviews Immunology thanks S. Nutt, who co-reviewed with M. Chopin, and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.
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Ginhoux, F., Guilliams, M. & Merad, M. Expanding dendritic cell nomenclature in the single-cell era. Nat Rev Immunol 22, 67–68 (2022). https://doi.org/10.1038/s41577-022-00675-7