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Innate IL-13 licenses dermal type 2 dendritic cells for efficient T helper 2 cell responses

Nature Reviews Immunology volume 21, page 275 (2021)Cite this article

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A Publisher Correction to this article was published on 20 April 2021

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Dendritic cells (DCs) are specialized in antigen presentation for T cell priming. Type 2 DCs (DC2s) excel at the induction of T helper 2 (TH2) cell and TH17 cell responses. However, the signals that control the ability of DC2s to prime TH2 cells versus TH17 cells remain unknown.

Previous work has shown that loss of Klf4 expression in DCs leads to the loss of migratory CD11blow DC2s in the skin-draining lymph nodes and loss of TH2 cell responses to house dust mite and Schistosoma mansoni infection. Now, Mayer, Lamiable and colleagues (preprint; non-peer reviewed) build on these results by showing that the differentiation of Klf4-dependent dermal CD11blow DC2s is dependent on IL-13 produced by group 2 innate lymphoid cells (ILC2s) and, to a lesser extent, by dendritic epidermal T cells in the normal skin. They also show that the absence of Klf4-dependent dermal CD11blow DC2s is associated with a strong reduction of TH2 cell responses against Nippostrongylus brasiliensis together with reduced transport of N. brasiliensis to the draining lymph nodes. By contrast, TH17 cell responses against Candida albicans were increased in mice lacking CD11blow DC2s.

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  • Mattiuz, R. Oxford–Mount Sinai (OxMS) Preprint Journal Club. OxMS https://www.preprintclub.com/2021-mar-mayer (2021)

  • Tussiwand, R. et al. Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses. Immunity 42, 916–928 (2015)

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  • Halim, T. Y. F. et al. Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation. Immunity 40, 425–435 (2014)

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  1. OxMS Preprint Journal Club, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Raphaël Mattiuz & Miriam Merad

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  1. Raphaël Mattiuz
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  2. Miriam Merad
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Correspondence to Raphaël Mattiuz or Miriam Merad.

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Mattiuz, R., Merad, M. Innate IL-13 licenses dermal type 2 dendritic cells for efficient T helper 2 cell responses. Nat Rev Immunol 21, 275 (2021). https://doi.org/10.1038/s41577-021-00552-9

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