Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Taking CAR T cells up a synthetic Notch

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


Original articles

  1. Choe, J. H. et al. Multi-antigen recognition circuits overcome challenges of specificity, heterogeneity, and durability in T cell therapy for glioblastoma. Preprint at bioRxiv (2021)

    Article  Google Scholar 

  2. Hyrenius-Wittsten, A. et al. Enhanced solid tumor recognition and T cell stemness with SynNotch CAR circuits. Preprint at bioRxiv (2021)

    Article  Google Scholar 

Related article

  1. Saffern, M. Oxford–Mount Sinai (OxMS) Preprint Journal Club. OxMS (2021)

Download references

Author information



Corresponding author

Correspondence to Miriam Saffern.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Saffern, M., Samstein, R. Taking CAR T cells up a synthetic Notch. Nat Rev Immunol 21, 135 (2021).

Download citation


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing