Fig. 1: SARS-CoV-2 infection can lead to neutrophilia-induced ROS release. | Nature Reviews Immunology

Fig. 1: SARS-CoV-2 infection can lead to neutrophilia-induced ROS release.

From: Tissue damage from neutrophil-induced oxidative stress in COVID-19

Fig. 1

a | In not at-risk individuals, an excess of reactive oxygen species (ROS) is counterbalanced by an increase in antioxidant defences. b | In subjects with impaired redox balance, ROS production is not properly controlled, leading to red blood cell (RBC) membrane peroxidation, which in turn perpetuates neutrophil activation. Excessive oxidative stress might be responsible for the alveolar damage, thrombosis and RBC dysregulation seen in COVID-19. Anti-oxidants and elastase inhibitors may have therapeutic potential.

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