In this preprint, Rodriguez et al. used mass cytometry and Olink to longitudinally profile immune cells and protein biomarkers in the blood of 39 patients with severe COVID-19 from acute infection to recovery. Partition-based graph abstraction identified IFNγ-induced CD62L+ eosinophils, which appeared 2–6 days after hospitalization. In addition, the authors highlight a correlation between IgG responses and circulating basophil numbers. Finally, integrating 148 plasma proteins and 63 immune cell populations in a multi-omics factor analysis identified potential cellular and plasma biomarkers of transition to recovery from severe COVID-19. This work supports further investigation into the role of eosinophils in lung hyperinflammation and the potential role of basophils in enhancing the humoral response to COVID-19.
References
Original article
Rodriguez, L. et al. Systems-level immunomonitoring from acute to recovery phase of severe COVID-19. Preprint at medRxiv https://doi.org/10.1101/2020.06.03.20121582 (2020)
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Tabachnikova, A., Chen, S.T. Roles for eosinophils and basophils in COVID-19?. Nat Rev Immunol 20, 461 (2020). https://doi.org/10.1038/s41577-020-0379-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41577-020-0379-1
This article is cited by
-
Bruton tyrosine kinase inhibitors in B-cell lymphoma: beyond the antitumour effect
Experimental Hematology & Oncology (2022)
-
Clinical and Laboratory Approach to Diagnose COVID-19 Using Machine Learning
Interdisciplinary Sciences: Computational Life Sciences (2022)
