Fig. 1: Proposed vessel–lung tissue interface in normal state and in COVID-19 disease. | Nature Reviews Immunology

Fig. 1: Proposed vessel–lung tissue interface in normal state and in COVID-19 disease.

From: COVID-19: the vasculature unleashed

Fig. 1

a | On the left, the normal interface between the alveolar space and endothelial cells is depicted; the right side highlights pathophysiological features of coronavirus disease 2019 (COVID-19) in the lung, including loss of vascular integrity (1), activation of the coagulation pathway (2) and inflammation (3). bd | Proposed contributing endothelial cell-specific mechanisms are detailed. ROS, reactive oxygen species; S1PR1, sphingosine 1 phosphate receptor 1; VWF, von Willebrand factor.

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