COVID-19

Immune correlates of SARS-CoV-2 protection

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The protective potential of SARS-CoV-2 neutralizing antibodies (nAbs) has not been validated in humans. This preprint study analysed an outbreak on a fishing vessel (n = 122) with an infection rate of 85%. Before departure, all individuals with available data (n = 120) were negative for SARS-CoV-2 infection by RT-PCR but 6 were positive for IgG against viral nucleoprotein. Of the 6 seropositive individuals, 3 had antibodies to SARS-CoV-2 spike protein and its receptor-binding domain (RBD) that could both neutralize pseudotyped lentiviruses and block the interaction between the RBD and the virus entry receptor ACE2. These 3 individuals did not get infected, unlike the 103 individuals who lacked pre-existing nAbs, suggesting that nAb titres are a correlate of viral immunity and, potentially, vaccine efficacy.

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  1. Addetia, A. et al. Neutralizing antibodies correlate with protection from SARS-CoV-2 in humans during a fishery vessel outbreak with high attack rate. Preprint at medRxiv https://doi.org/10.1101/2020.08.13.20173161 (2020)

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Correspondence to Matthew Brown.

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The author declares no competing interests.

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Brown, M. Immune correlates of SARS-CoV-2 protection. Nat Rev Immunol 20, 593 (2020). https://doi.org/10.1038/s41577-020-00442-6

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