CD8+ T cells remember same bits of SARS-CoV-2


Deciphering the epitope dominance of the natural memory responses seen in recovered patients with COVID-19 will aid vaccine development. In this preprint, Ferretti et al. used an unbiased genome-wide screen (T-Scan) to map the epitopes recognized by memory CD8+ T cells from convalescent patients with COVID-19 with prevalent HLA types. SARS-CoV-2-specific memory CD8+ T cells recurrently targeted a limited set of immunodominant epitopes, which were unique to SARS-CoV-2 and not from highly variable regions. Only 10% of these epitopes corresponded to the S protein, stressing the relevance of developing vaccines that promote T cell responses against other viral targets, such as ORF1ab and N protein.


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  1. Ferretti, A. P. et al. COVID-19 patients form memory CD8+ T cells that recognize a small set of shared immunodominant epitopes in SARS-CoV-2. Preprint at medRxiv (2020)

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Correspondence to Julie M. Mazet or Ester Gea-Mallorquí.

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Mazet, J.M., Gea-Mallorquí, E. CD8+ T cells remember same bits of SARS-CoV-2. Nat Rev Immunol 20, 592 (2020).

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