Using a high-throughput approach, Snyder et al. profile clonally expanded SARS-CoV-2-specific CD8+ T cells both at the individual level, mapping T cell receptors (TCRs) to 545 predicted HLA class I-binding peptides in 61 acute and convalescent patients with COVID-19, and at the population level, decoding shared COVID-19-associated TCRs in 1,015 patients versus control subjects. In total, this preprint identifies 23,179 unique virus-specific TCRs spanning the entire SARS-CoV-2 proteome. Importantly, HLA haplotypes were found to determine both clonal breadth and depth of an individual’s virus-specific CD8+ T cell response. By applying a logistic regression classifier, the authors show that publicly shared CD8+ TCRs may be used as a potential biomarker of current and past SARS-CoV-2 infection at high specificity and sensitivity.
Snyder, T. M. et al. Magnitude and dynamics of the T-cell response to SARS-CoV-2 infection at both individual and population levels. Preprint at medRxiv https://doi.org/10.1101/2020.07.31.20165647 (2020)
The authors declare no competing interests.
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Levantovsky, R., van der Heide, V. Shared CD8+ T cell receptors for SARS-CoV-2. Nat Rev Immunol 20, 591 (2020). https://doi.org/10.1038/s41577-020-00433-7
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