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Antibody response to SARS-CoV-2 — sustained after all?


Recent studies have indicated that antibody responses to SARS-CoV-2 drop significantly within 2 months. In this preprint, Wu et al. analysed antibody responses in 349 individuals who were among the first to become infected with SARS-CoV-2. All antiviral antibody titres significantly increased in the first weeks after disease onset, followed by a contraction phase, where IgM became undetectable at around week 10–13. Importantly, although Spike-targeted IgG (IgG-S) declined over time, it remained detectable at relatively high levels until the end of the 6-month study period. IgG-S titres correlated closely with neutralizing capacity, although exact correlates of protection for SARS-CoV-2 are still elusive. These results suggest that antibody responses in symptomatic patients with COVID-19 follow a prototypical progression and result in a sustained memory response, suggesting long-term protective immunity.


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Correspondence to Ewoud B. Compeer.

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Compeer, E.B., Uhl, L.F.K. Antibody response to SARS-CoV-2 — sustained after all?. Nat Rev Immunol 20, 590 (2020).

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