Recent studies have indicated that antibody responses to SARS-CoV-2 drop significantly within 2 months. In this preprint, Wu et al. analysed antibody responses in 349 individuals who were among the first to become infected with SARS-CoV-2. All antiviral antibody titres significantly increased in the first weeks after disease onset, followed by a contraction phase, where IgM became undetectable at around week 10–13. Importantly, although Spike-targeted IgG (IgG-S) declined over time, it remained detectable at relatively high levels until the end of the 6-month study period. IgG-S titres correlated closely with neutralizing capacity, although exact correlates of protection for SARS-CoV-2 are still elusive. These results suggest that antibody responses in symptomatic patients with COVID-19 follow a prototypical progression and result in a sustained memory response, suggesting long-term protective immunity.
Wu, J. et al. SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19. Preprint at medRxiv https://doi.org/10.1101/2020.07.21.20159178 (2020)
The authors declare no competing interests.
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Compeer, E.B., Uhl, L.F.K. Antibody response to SARS-CoV-2 — sustained after all?. Nat Rev Immunol 20, 590 (2020). https://doi.org/10.1038/s41577-020-00423-9