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CANCER IMMUNOTHERAPY

CD3ε tunes CAR T cell anticancer activity

Nature Reviews Immunology volume 20, pages 520–521 (2020)Cite this article

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Chimeric antigen receptor (CAR) T cells express engineered receptors that allow for the recognition of specific antigens, such as cancer antigens, via their extracellular domain and cellular activation via their intracellular domain. The intracellular domain usually contains a signalling domain derived from the T cell receptor (TCR) subunit CD3ζ. Reporting in Cell, Wu et al. now present a new method to examine the signalling patterns of the TCR signalling subunits and show that CD3ε may serve as a useful module in CAR T cell engineering.

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  1. Nature Reviews Immunology http://www.nature.com/nri/

    Alexandra Flemming

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  1. Alexandra Flemming
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Correspondence to Alexandra Flemming.

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Flemming, A. CD3ε tunes CAR T cell anticancer activity. Nat Rev Immunol 20, 520–521 (2020). https://doi.org/10.1038/s41577-020-00418-6

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  • DOI: https://doi.org/10.1038/s41577-020-00418-6

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