The Western lifestyle has lasting effects on metaflammation

Chronic consumption of a Western diet along with sedentary behaviour causes chronic metabolic inflammation (termed metaflammation) and is ‘memorized’ by innate immune cells through long-lasting metabolic and epigenetic cellular reprogramming. Lifestyle-associated pathologies have reached epidemic proportions and require a better understanding of the causes of metaflammation and ways to translate this to measures that protect the public from unhealthy diets.

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Fig. 1: Risk factors and mitigation for metaflammation.

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Acknowledgements

This work was supported by the European Research Council consolidator grant InflammAct, the US National Institutes of Health grant 1R01HL112661 and grants provided by the Deutsche Forschungsgesellschaft EXC2151 — 390873048, SFB 1123; TRRs 83, 57.

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Correspondence to Eicke Latz.

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E.L. is co-founder and consultant of IFM Therapeutics. A.C. declares no competing interests.

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Christ, A., Latz, E. The Western lifestyle has lasting effects on metaflammation. Nat Rev Immunol 19, 267–268 (2019). https://doi.org/10.1038/s41577-019-0156-1

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