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Are tolerance and training required to end TB?

Host defence strategies against Mycobacterium tuberculosis (Mtb), the bacterium that causes tuberculosis (TB), include host resistance and disease tolerance. To date, most studies have focused on resistance mechanisms, but developing new strategies to eradicate Mtb will require an understanding of the entire landscape of immunity in TB. Here I discuss two evolutionarily conserved host defence strategies, disease tolerance and trained immunity (memory-like innate immune responses), and their role in Mtb infection.

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This work was supported by the Canadian Institute of Health Research (CIHR) Foundation Grant (FDN-143273) to M.D. and M.D. holds a Fonds de la Recherche du Quebec- Sante (FRQS) Award and the Strauss Chair in Respiratory Diseases.

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The author declares no competing interests.

Correspondence to Maziar Divangahi.

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Fig. 1: Nuts and bolts of trained immunity.