Abstract
Antimicrobial resistance (AMR) — the ability of microorganisms to adapt and survive under diverse chemical selection pressures — is influenced by complex interactions between humans, companion and food-producing animals, wildlife, insects and the environment. To understand and manage the threat posed to health (human, animal, plant and environmental) and security (food and water security and biosecurity), a multifaceted ‘One Health’ approach to AMR surveillance is required. Genomic technologies have enabled monitoring of the mobilization, persistence and abundance of AMR genes and mutations within and between microbial populations. Their adoption has also allowed source-tracing of AMR pathogens and modelling of AMR evolution and transmission. Here, we highlight recent advances in genomic AMR surveillance and the relative strengths of different technologies for AMR surveillance and research. We showcase recent insights derived from One Health genomic surveillance and consider the challenges to broader adoption both in developed and in lower- and middle-income countries.
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Acknowledgements
The authors thank F. MacIver from the University of Technology Sydney for assistance with preparing and editing the manuscript and S. Zufan from the University of Melbourne for assistance with preparation of Fig. 3. This work was supported by the Medical Research Future Fund (MRFF)-supported AusPathoGen Program (FSPGN000049) and by the Australian Centre for Genomic Epidemiological Microbiology (Ausgem), a collaborative research initiative between the New South Wales Department of Primary Industries and the University of Technology Sydney. B.P.H. is supported by a National Health and Medical Research Council (NHMRC) Fellowship (GNT1196103).
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S.P.D., V.M.J., T.S., M.L.C., A.E.W., B.D., E.D. and B.P.H. researched the literature. S.P.D., V.M.J., T.S., M.L.C., A.E.W., E.R.W., C.J.R., E.D. and B.P.H. contributed substantially to discussions of the content. S.P.D., V.M.J., T.S., M.L.C., E.D. and B.P.H. wrote the article. S.P.D., V.M.J., T.S., A.E.W., B.D., C.J.R., E.D. and B.P.H. reviewed and/or edited the manuscript before submission.
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Djordjevic, S.P., Jarocki, V.M., Seemann, T. et al. Genomic surveillance for antimicrobial resistance — a One Health perspective. Nat Rev Genet 25, 142–157 (2024). https://doi.org/10.1038/s41576-023-00649-y
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DOI: https://doi.org/10.1038/s41576-023-00649-y