With age, somatic mutations accumulate in the genome of healthy individuals, but the functional outcome of this increased mutational load has been unclear. Recent sequencing data support a functional role for somatic mutations in ageing and age-associated diseases.
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Acknowledgements
We thank R. Sitia and A. Boletta for discussions. I.F. is supported by Marie Sklodowska-Curie individual fellowship 896832-SoMuKT.
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Franco, I., Eriksson, M. Reverting to old theories of ageing with new evidence for the role of somatic mutations. Nat Rev Genet 23, 645–646 (2022). https://doi.org/10.1038/s41576-022-00513-5
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DOI: https://doi.org/10.1038/s41576-022-00513-5
