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From Mendel to a Mendelian disorder: towards a cure for sickle cell disease

In celebrating the bicentenary of Gregor Mendel’s birth, we reflect on progress and future directions in the application of genetics and genomics to delivering a cure for sickle cell disease, a classic Mendelian disorder that affects 5 million people globally, most of whom are in Africa.

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We thank all those from whom we have learned genetics, all those who have made advances in gene therapy, and all of our patients with sickle cell disease.

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Correspondence to Julie Makani.

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Makani, J., Nkya, S., Collins, F. et al. From Mendel to a Mendelian disorder: towards a cure for sickle cell disease. Nat Rev Genet 23, 389–390 (2022).

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