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The magic and meaning of Mendel’s miracle

Nature Reviews Genetics volume 23, pages 447–452 (2022)Cite this article

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Abstract

July 2022 will see the bicentenary of the birth of Gregor Mendel, often hailed as the ‘father of modern genetics’. To mark the occasion, I retrace Mendel’s origins, revisit his famous study ‘Experiments in plant hybridization’, and reflect on the revolutionary implications of his work and scientific legacy that continues to shape modern biomedicine to this day.

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References

  1. Bentley, D. R. et al. Accurate whole human genome sequencing using reversible terminator chemistry. Nature 456, 53–59 (2008).

    Article  CAS  Google Scholar 

  2. Smith, G. D. & Ebrahim, S. ‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease? Int. J. Epidemiol. 32, 1–22 (2003).

    Article  Google Scholar 

  3. Liu, Y. et al. Expanded diversity of Asgard archaea and their relationships with eukaryotes. Nature 593, 553–557 (2021).

    Article  CAS  Google Scholar 

  4. Jinek, M. et al. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337, 816–821 (2012).

    Article  CAS  Google Scholar 

  5. Maxwell, J. C. A dynamical theory of the electromagnetic field. Philos. Soc. R. Soc. Lond. 155, 459–512 (1865).

    Google Scholar 

  6. Abbott, S. & Fairbanks, D. J. Experiments on plant hybrids by Gregor Mendel. Genetics 204, 407–422 (2016).

    Article  Google Scholar 

  7. Mendel, G. Versuche ueber planzenhybriden Verh. Nat. Ver. Bruenn 4, 3–44 (1866).

    Google Scholar 

  8. Flemming, W. Beiträge zur Kenntnisse der Zelle und ihrer Lebenserscheinungen. Arch. Mikrosk. Anat. 16, 302–436 (1879).

    Article  Google Scholar 

  9. Boveri, T. Ueber mehrpolige mitosen als mittel zur analyse des zellkerns. Verh. Phys. Med. Gesellsch. Wuerzburg 35, 67–90 (1902).

    Google Scholar 

  10. Beneden, E. V. Researches sur la maturation de l’oeuf et la fecondation. Arch. Biol. Paris 4, 265–638 (1883).

    Google Scholar 

  11. Sutton, W. S. The chromosomes in heredity. Biol. Bull. 4, 231–251 (1903).

    Article  Google Scholar 

  12. Darwin, C. R. & Wallace, A. R. On the tendency of species to form varieties; and on the perpetuation of varieties and species by natural means of selection. Zool. J. Linn. Soc. 3, 45–62 (1858).

    Article  Google Scholar 

  13. Kimura, M. The Neutral Theory of Molecular Evolution. (Cambridge University Press, 1983).

  14. Mawer, S. Gregor Mendel Planting the Seeds of Genetics (Abrams, 2006).

  15. Gliboff, S. Evolution, revolution, and reform in Vienna: Franz Unger’s ideas on descent and their post-1848 reception. J. Hist. Biol. 31, 179–209 (1998).

    Article  Google Scholar 

  16. Darwin, C. On the Origin of Species by Means of Natural Selection (John Murray, 1859).

  17. Malthus, T. R. An Essay on the Principle of Population (J. Johnson, 1798).

  18. Popper, K. Objective Knowledge: An Evolutionary Approach (Clarendon, 1972).

  19. Charlesworth, B. & Charlesworth, D. Darwin and genetics. Genetics 183, 757–766 (2009).

    Article  Google Scholar 

  20. Naegili, C. W. Mechanisch-Physiologische Theorie der Abstammunglehre (Max Planck Institute for the History of Science, 1884).

  21. Fairbanks, D. J. Mendel and Darwin: untangling a persistent enigma. Heredity 124, 263–273 (2020).

    Article  Google Scholar 

  22. Darwin, C. R. The Variations of Animals and Plants Under Domestication (John Murray, 1868).

  23. Iltis, H. Gregor Mendel and his work. Sci. Monthly 56, 414–423 (1943).

    Google Scholar 

  24. Fisher, R. A. Has Mendel’s work been re-discovered? Ann. Sci. 1, 115–137 (1936).

    Article  Google Scholar 

  25. Beadle, G. W. & Tatum, E. L. Genetic control of biochemical reactions in neurospora. Proc. Natl Acad. Sci. USA 27, 499–506 (1941).

    Article  CAS  Google Scholar 

  26. Crick, F. H. in Symposia of Society for Experimental Biology (Cambridge University Press, 1958).

  27. Sturtevant, A. H. The linear arrangement of six sex-linked factors in Drosophila, as shown by their mode of association. J. Exp. Biol. 14, 43–59 (1913).

    Google Scholar 

  28. van Dijk, P. J. & Ellis, T. H. The full breadth of Mendel’s genetics. Genetics 204, 1327–1336 (2016).

    Article  Google Scholar 

  29. Watson, J. D. & Crick, F. H. C. A structure for deoxyribonucleic acid. Nature 171, 737–738 (1953).

    Article  CAS  Google Scholar 

  30. Jacob, F. The Statue Within (Basic Books, 1988).

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Acknowledgements

The author thanks B. Charlesworth and M. Srinivasan for helpful comments on the manuscript.

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  1. Department of Biochemistry, University of Oxford, Oxford, United Kingdom

    Kim Nasmyth

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  1. Kim Nasmyth
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Correspondence to Kim Nasmyth.

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Nasmyth, K. The magic and meaning of Mendel’s miracle. Nat Rev Genet 23, 447–452 (2022). https://doi.org/10.1038/s41576-022-00497-2

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