Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

HUMAN GENETICS

Organoids reveal the neurodevelopmental consequences of mutations

Nature Reviews Genetics volume 23, page 195 (2022)Cite this article

Subjects

Identifying the underlying cellular and molecular mechanisms by which mutations cause human neurological disorders requires model systems that recapitulate key aspects of human brain development and function. Two new studies of mutations linked to distinct neurological conditions — autism spectrum disorders (ASD) and tuberous sclerosis complex (TSC) — use human brain organoids to identify mutation-driven alterations to cell lineage trajectories during early brain development.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

Buy

All prices are NET prices.

References

Original articles

  • Paulsen, B. et al. Autism genes converge on asynchronous development of shared neuron classes. Nature 602, 268–273 (2022)

    Article  CAS  Google Scholar 

  • Eichmüller, O. L. et al. Amplification of human interneuron progenitors promotes brain tumors and neurological defects. Science 375, eabf5546 (2022)

    Article  Google Scholar 

Related article

  • Rossi, G., Manfrin, A. & Lutolf, M. P. Progress and potential in organoid research. Nat. Rev. Genet. 19, 671–687 (2018)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nature Reviews Genetics http://www.nature.com/nrg/

    Darren J. Burgess

Authors
  1. Darren J. Burgess
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Darren J. Burgess.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Burgess, D.J. Organoids reveal the neurodevelopmental consequences of mutations. Nat Rev Genet 23, 195 (2022). https://doi.org/10.1038/s41576-022-00467-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41576-022-00467-8

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer