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CANCER GENOMICS

Using tumour phylogenies to identify drivers

Nature Reviews Genetics volume 23, page 196 (2022)Cite this article

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Pinpointing the timing of somatic driver mutations, so called because they ‘drive’ cancer initiation and progression, could help with early detection and intervention strategies. In Nature, Williams et al. reconstruct haematopoietic phylogenies and track clonal evolutionary dynamics in 12 patients with adult-onset myeloproliferative neoplasms, revealing that initial driver mutations of these cancers often occur during childhood, including in utero.

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References

Original article

  • Williams, N. et al. Life histories of myeloproliferative neoplasms inferred from phylogenies. Nature 602, 162–168 (2022)

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Related article

  • Silver, A. J., Bick, A. G. & Savona, M. R. Germline risk of clonal haematopoiesis. Nat. Rev. Genet. 22, 603–617 (2021)

    Article  CAS  Google Scholar 

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  1. Nature Reviews Genetics http://www.nature.com/nrg/

    Linda Koch

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  1. Linda Koch
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Correspondence to Linda Koch.

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Koch, L. Using tumour phylogenies to identify drivers. Nat Rev Genet 23, 196 (2022). https://doi.org/10.1038/s41576-022-00458-9

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  • DOI: https://doi.org/10.1038/s41576-022-00458-9

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