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Biparental inheritance of mitochondrial DNA revisited

Evidence for a biparental mode of mitochondrial DNA (mtDNA) inheritance has been sparse and remains controversial. Recent studies using a range of complementary techniques do not support paternal transmission of mtDNA and highlight the co-amplification of rare, concatenated nuclear mtDNA segments as a technical artefact that may explain previous observations.

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The authors acknowledge funding from the Wellcome Trust (203141/Z/16/Z and 212219/Z/18/Z), the Medical Research Council Mitochondrial Biology Unit (MC_UU_00015/9) and the NIHR Biomedical Research Centres at Cambridge, Oxford and Great Ormond Street.

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Correspondence to Patrick F. Chinnery.

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Pagnamenta, A.T., Wei, W., Rahman, S. et al. Biparental inheritance of mitochondrial DNA revisited. Nat Rev Genet 22, 477–478 (2021).

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