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GENOMICS

Spaceflight causes mitochondrial stress

Nature Reviews Genetics volume 22, page 69 (2021)Cite this article

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In this Cell article, the health risks of spaceflight are investigated by a wide-ranging analysis of transcriptomic, epigenomic, proteomic and metabolomic data from NASA’s GeneLab. GeneLab contains data for 59 astronauts and hundreds of samples that have been flown in space, including mouse strains, human cell models, and mouse and human tissues. Pathway analyses implicated mitochondrial stress and dysregulation as major drivers of health risks, and some key findings were confirmed using data from the NASA Twin study.

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References

Original article

  • da Silveira, W. A. et al. Comprehensive multi-omics analysis reveals mitochondrial stress as a central biological hub for spaceflight impact. Cell 183, 1185–1201 (2020)

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  1. Nature Reviews Genetics

    Dorothy Clyde

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  1. Dorothy Clyde
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Correspondence to Dorothy Clyde.

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Clyde, D. Spaceflight causes mitochondrial stress. Nat Rev Genet 22, 69 (2021). https://doi.org/10.1038/s41576-020-00322-8

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  • DOI: https://doi.org/10.1038/s41576-020-00322-8

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