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Pancreatic cancer

Unlocking the promise of RAS inhibition in pancreatic cancer

The advent of next-generation RAS inhibitors brings renewed optimism to the care of patients with pancreatic cancer after decades of failure for novel therapeutics. A recent study highlights the potent antitumour activity of the multi-selective RAS(ON) inhibitor RMC-7977 across a spectrum of preclinical pancreatic cancer models.

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Fig. 1: Mutant KRAS drives oncogenesis in PDAC via cell-intrinsic and cell-extrinsic mechanisms.

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Correspondence to Nilofer S. Azad.

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N.S.A. reports clinical research funding and consultant/advisory fees from Revolution Medicines, Mirati Therapeutics and Bristol Myers Squibb. S.D.H. declares no competing interests.

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Haldar, S.D., Azad, N.S. Unlocking the promise of RAS inhibition in pancreatic cancer. Nat Rev Gastroenterol Hepatol (2024). https://doi.org/10.1038/s41575-024-00951-y

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