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NASH

Role of intestinal B cells in NASH and liver fibrosis

Nature Reviews Gastroenterology & Hepatology volume 20, page 630 (2023)Cite this article

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The gut–liver axis is known to have a role in nonalcoholic steatohepatitis (NASH) and in NASH-induced fibrosis and hepatocellular carcinoma (HCC), but the precise mechanisms are unknown. In a study published in the Journal of Hepatology, researchers identify mechanisms by which intestinal B cells are implicated in the pathogenesis and progression of NASH and liver fibrosis.

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References

Original article

  • Kotsiliti, E. et al. Intestinal B cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling. J. Hepatol. 79, 296–313 (2023)

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  1. Nature Reviews Gastroenterology & Hepatology http://www.nature.com/nrgastro/

    Jordan Hindson

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  1. Jordan Hindson
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Correspondence to Jordan Hindson.

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Hindson, J. Role of intestinal B cells in NASH and liver fibrosis. Nat Rev Gastroenterol Hepatol 20, 630 (2023). https://doi.org/10.1038/s41575-023-00845-5

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  • DOI: https://doi.org/10.1038/s41575-023-00845-5

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