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IBD

Combination therapies: the next major frontier in IBD management

Nature Reviews Gastroenterology & Hepatology volume 20, page 761 (2023)Cite this article

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Treatment strategies that combine therapies have revolutionized management across multiple areas of medicine. In inflammatory bowel disease (IBD), there have been a welcome number of new medication options for patients, but a ‘therapeutic ceiling’ has emerged in which no single treatment seems to be effective in any more than 20–30% of patients. Despite there being more options than ever before, one of the major worries about combining advanced therapies in IBD has been the potential risk of adverse effects from adopting such an approach.

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References

Original article

  • Colombel, J. F. et al. Infliximab, azathioprine, or combination therapy for Crohn’s disease. N. Engl. J. Med. 362, 1383–1395 (2010)

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Related article

  • Feagan, B. G. et al. Guselkumab plus golimumab combination therapy versus guselkumab or golimumab monotherapy in patients with ulcerative colitis (VEGA): a randomised, double-blind, controlled, phase 2, proof-of-concept trial. Lancet Gastroenterol. Hepatol. 8, 307–320 (2023)

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Authors and Affiliations

  1. Department of Gastroenterology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

    Nurulamin M. Noor

  2. Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK

    Nurulamin M. Noor

  3. Medical Research Council Clinical Trials Unit, University College London, London, UK

    Nurulamin M. Noor

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  1. Nurulamin M. Noor
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Correspondence to Nurulamin M. Noor.

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Cite this article

Noor, N.M. Combination therapies: the next major frontier in IBD management. Nat Rev Gastroenterol Hepatol 20, 761 (2023). https://doi.org/10.1038/s41575-023-00839-3

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  • DOI: https://doi.org/10.1038/s41575-023-00839-3

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